منابع مشابه
The renal medullary microcirculation.
Blood flow to the renal medulla is supplied through descending vasa recta (DVR), which are derived from the efferent arterioles of juxtamedullary glomeruli. In addition to their role as conduits for blood flow, it is accepted that the vasa recta are countercurrent exchangers. That process, however, involves events which are more complicated than paracellular diffusive exchange of NaCl and urea....
متن کاملPhysiology of the renal medullary microcirculation.
Perfusion of the renal medulla plays an important role in salt and water balance. Pericytes are smooth muscle-like cells that impart contractile function to descending vasa recta (DVR), the arteriolar segments that supply the medulla with blood flow. DVR contraction by ANG II is mediated by depolarization resulting from an increase in plasma membrane Cl(-) conductance that secondarily gates vol...
متن کاملDiabetes-induced alterations in renal medullary microcirculation and metabolism.
Diabetes-induced renal complications, i.e. diabetes nephropathy, are a major cause of morbidity and mortality. The exact mechanisms mediating the negative influence of hyperglycemia on renal function are unclear, although several hypotheses have been postulated. Cellular mechanisms include glucose-induced excessive formation of reactive oxygen species, increased glucose flux through polyol path...
متن کاملDeterminants of basal nitric oxide concentration in the renal medullary microcirculation.
In this study, we modeled the production, transport, and consumption of nitric oxide (NO) in the renal medullary microcirculation under basal conditions. To yield agreement with reported NO concentrations of approximately 60-140 nM in medullary tissues (Zou AP and Cowley AW Jr. Hypertension 29: 194-198, 1997; Am J Physiol Regul Integr Comp Physiol 279: R769-R777, 2000) and 3 nM in plasma (Staml...
متن کاملTheoretical effects of UTB urea transporters in the renal medullary microcirculation.
A mathematical model of transport in the renal medullary microcirculation was used to investigate the role of the UTB urea transporter expressed in descending vasa recta (DVR) endothelia and red blood cell (RBC) membranes. Our simulations suggest that UTB raises RBC and plasma and interstitial urea concentrations by facilitating radial diffusion of the solute and therefore serves to increase th...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 2000
ISSN: 1093-9946,1093-4715
DOI: 10.2741/edwards